When it comes chronic inflammation of the arteries and veins of the extremities, often lower, combined with multiple thrombosis.Alternating periods of exacerbation and attenuation of inflammation in disease progression is often in a state of severe ulcers and gangrene. At this stage most often requires amputation of the affected limb.
Byurgerova disease pathogenesis is not well understood, but it is certainly the importance of tobacco smoke and nicotine for her initiation is assumed that a type of autoimmune disorder that is triggered under the influence of constituents in cigarette smoke.Gender is also important - women suffer twice as often than women.
Byurgerova disease is not life-threatening disease, but greatly reduces the quality of life - pain in the extremities and subsequent complications make it difficult for everyday activities and even self.
Interestingly, although it is an illness with inflammation of blood vessels and thrombosis, inflammatory and thrombolytic drugs have minimal effect. The highest therapeutic value is quitting, the greatest slowing the progression observed in humans gave up smoking after diagnosis. Accordingly, they most often leads to complications and amputations.
Perhaps the most famous person suffering from this disease, the English King George VI. In his book "God Save the Queen" (God save the Queen) Alan Mitchie wrote that the King was diagnosed with Byurgerova disease at the end of 1948 or early 1949 after failing to abandon his passion for cigarettes King underwent surgery to remove the nerve ganglion, in 1949
The disease, known as obliterative tromboangiit (Tromboangiitis obliterans), named Leo Buerger, who first described it in 1908